报告题目:Dr. Trucu’s research interests is placed in the areas of

报告人：Dumitru Trucu PhD

报告时间：下午3点半

报告地点：理A110

讲座时间：11月3号，下午3点半

讲座地点：理A110

讲座人： Dumitru Trucu  PhD

Dr. Trucu’s research interests is placed in the areas of: (1) multiscale computational modelling and analysis of cancer
invasion; and (2) inverse problems, focused on data assimilation in biological modelling. Dr. Trucu’s current research
interests focus on further advancing the multiscale moving boundary computational modelling framework that he recently
introduced. He is currently exploring its dynamics under more complex tissue-scale and cell-scale interactions and applying
the framework specifically to modelling breast cancer invasion. This includes: (1) accounting for molecular signaling
mechanisms occurring at the cell-scale level (induced by the dynamics of both various proteolytic enzyme families and
calcium ion-based trans-membrane adhesion processes) and their contribution to tumour progression at the tissue-scale; (2)
considering additional cell types at the tissue-scale (e.g. immuno-inflammatory cells, endothelial cells, and cancer-
associated fibroblasts); (3) investigating the effects of cell-cell and cell-matrix adhesion properties in cancer invasion; (4)
advancing the associated multiscale computational platform; and (5) further developing the novel multiscale analysis
framework based on the concept of three-scale convergence that he recently introduced. Additionally, Dr. Trucu is
developing an inverse-problem approach to data assimilation in cancer modelling. This focuses on estimating the
macroscopic thickness and spatial distribution of the outer proliferating rim in an invading solid tumour, crucially using the
modelling to determine the extent of resection required in future clinical applications.
Dr. Trucu was an invited plenary speaker at the following international conferences: (1) CIMPA Summer Research School
in "Mathematical modeling in Biology and Medicine”, 08-17 June 2016, Oriente University, Santiago de Cuba, Cuba; (2)
New Mathematical and Computational Problems involved in Cell Motility, Morphogenesis and Pattern Formation, 07-11
December 2015, Isaac Newton Institute, Cambridge, UK; (3) Perspectives in Environmental and Systems Biology, 13-15
April 2015, Université Joseph Fourier in Grenoble, France; (4) International Conference on Mathematics for the Natural
and Life Sciences, 9-11 November 2014, University of Tlemcen, Algeria; (5) ESMTB Summer School: Mathematical
Models and Methods for Living Systems, 1-6 September 2014, Levico Terme, Italy; (6) Kepler Workshop on Complex
Living Systems: Managing Complexity, Reducing Perplexity, 16-20 May 2011, University of Heidelberg, Germany.
Together with University of Dundee colleagues, Dr. Raluca Eftimie and Prof. Ping Lin, Dr. Trucu organised the
International Workshop on Numerical Methods and Emerging Computational Challenges in Mathematical Biology, 12-15
May 2014, University of Dundee, Dundee. Additionally, Dr. Trucu and fellow PI Prof. Mark Chaplain organised the
international workshop on Computational and Multiscale Mathematical Modelling of Cancer Growth and Spread, 22-26
June 2015, International Centre for Mathematical Science, Edinburgh. Finally, Dr Trucu and Dr Raluca Eftimie organised
the Porous Media Modelling in Biological Processes: Perspectives on Analytical and Computational Methods Enabling
Data Inversion, 27-28 August 2015, University of Dundee, Dundee.
Dr. Trucu has graduated 1 PhD student and currently supervises 3 PhD students including one supported by an EPSRC
DTA studentship awarded competitively to him by the University of Dundee.