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博学堂讲座
Periodicity and Synchronization in Malaria Infection with Immune Response --- with an Introduction of Research by some Nobel Laureates in Medicine or Physiology (第200讲)
浏览量：1464    发布时间：2016-10-17 12:48:33

报告题目:Periodicity and Synchronization in Malaria Infection with Immune Response --- with an Introduction of Research by some Nobel Laureates in Medicine or Physiology

报告人：阮士贵教授

报告时间：15:30-17:20

报告地点：健B112

讲座题目：Periodicity and Synchronization in Malaria Infection with Immune Response --- with an Introduction of Research by some Nobel Laureates in Medicine or Physiology 
“疟疾传染免疫应答的周期性与同步性
－－若干诺贝尔医学或生理奖工作简介”
讲座时间：10月19日(周三) 下午 15:30—16:20（上）；16:30—17:20（下）。  
讲座地点：健B112
报告人：Shigui Ruan （阮士贵）教授
摘要： 
On October 3, 2011, three scientists (Bruce A. Beutler, Jules A. Hoffmann and Ralph M. Steinman) won Nobel Prizes in Medicine or Physiology for their discoveries on how the innate and adaptive phases of the immune response are activated and thereby provide novel insights into disease mechanisms. Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases. In this talk I’ll use malaria as an example to explain how both innate immunity and adaptive immunity fight against malaria infection and to model the within-host dynamics of malaria infection with immune response. For the ODE model consisted of healthy red blood cells, infected red blood cells, malaria parasitemia, and immune effectors, conditions on the existence and stability of both infection equilibria are given and it is shown that the model can exhibit periodic oscillations. Using the Hopf bifurcation theorem for abstract Cauchy problems in which the linear operator is not densely defined and is not a Hille-Yosida operator, it is shown that the age-structured malaria model of infected red blood cells (Rouzine and McKenzie, Proc Natl Acad Sci USA, 2003) undergoes Hopf bifurcation when the replication rate is used as the bifurcation parameter. Both mathematical analysis and numerical simulations confirm the observation of Kwiatkowski and Nowak (Proc Natl Acad Sci USA,1991) that synchronization with regular periodic oscillations (of period 48 h) occurs in malaria infection with modest replication rates.
报告人简介：
阮士贵教授是美国迈阿密大学(University of Miami)数学系的终身教授。作为项目负责人多次主持美国国家科学基金(NSF)项目和美国国家卫生研究院（NIH）基金项目，获得中国国家自然科学基金委“海外及港澳学者合作研究基金”（原海外杰出青年基金）项目资助。
    阮士贵教授的研究领域是动力系统、微分方程和生物数学，在反应扩散方程、抽象空间半线性方程动力学、生物动力系统等方面建立了一系列重要的理论，在多种传染病（特别是在我国流行的一些重大传染病）的建模与防治方面作了一系列重要工作，在包括《PNAS(美国国家科学院院刊)》、《Memoirs of Amer. Math. Soc.》、《Clinical Infectious Diseases(临床传染病)》、《Arch. Ration. Mech. Anal.》和《Journal de Mathématiques Pures et Appliquées》的国际顶尖学术期刊上发表了一系列高水平的学术论文，被SCI 收录100多篇文章，受到了国内外同行的关注与大量引用，2014 年和2015年连续被汤森路透(Thomson Reuters) 列为全球高引用科学家(Highly Cited Researcher)（世界第八）；据美国数学会的MathSciNet统计，截止2016年4月底其论文被1700多位作者引用了2500多次。
 
 
 
 
博学堂讲座
Periodicity and Synchronization in Malaria Infection with Immune Response --- with an Introduction of Research by some Nobel Laureates in Medicine or Physiology (第200讲)
浏览量：1464    发布时间：2016-10-17 12:48:33

报告题目:Periodicity and Synchronization in Malaria Infection with Immune Response --- with an Introduction of Research by some Nobel Laureates in Medicine or Physiology

报告人：阮士贵教授

报告时间：15:30-17:20

报告地点：健B112

讲座题目：Periodicity and Synchronization in Malaria Infection with Immune Response --- with an Introduction of Research by some Nobel Laureates in Medicine or Physiology 
“疟疾传染免疫应答的周期性与同步性
－－若干诺贝尔医学或生理奖工作简介”
讲座时间：10月19日(周三) 下午 15:30—16:20（上）；16:30—17:20（下）。  
讲座地点：健B112
报告人：Shigui Ruan （阮士贵）教授
摘要： 
On October 3, 2011, three scientists (Bruce A. Beutler, Jules A. Hoffmann and Ralph M. Steinman) won Nobel Prizes in Medicine or Physiology for their discoveries on how the innate and adaptive phases of the immune response are activated and thereby provide novel insights into disease mechanisms. Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases. In this talk I’ll use malaria as an example to explain how both innate immunity and adaptive immunity fight against malaria infection and to model the within-host dynamics of malaria infection with immune response. For the ODE model consisted of healthy red blood cells, infected red blood cells, malaria parasitemia, and immune effectors, conditions on the existence and stability of both infection equilibria are given and it is shown that the model can exhibit periodic oscillations. Using the Hopf bifurcation theorem for abstract Cauchy problems in which the linear operator is not densely defined and is not a Hille-Yosida operator, it is shown that the age-structured malaria model of infected red blood cells (Rouzine and McKenzie, Proc Natl Acad Sci USA, 2003) undergoes Hopf bifurcation when the replication rate is used as the bifurcation parameter. Both mathematical analysis and numerical simulations confirm the observation of Kwiatkowski and Nowak (Proc Natl Acad Sci USA,1991) that synchronization with regular periodic oscillations (of period 48 h) occurs in malaria infection with modest replication rates.
报告人简介：
阮士贵教授是美国迈阿密大学(University of Miami)数学系的终身教授。作为项目负责人多次主持美国国家科学基金(NSF)项目和美国国家卫生研究院（NIH）基金项目，获得中国国家自然科学基金委“海外及港澳学者合作研究基金”（原海外杰出青年基金）项目资助。
    阮士贵教授的研究领域是动力系统、微分方程和生物数学，在反应扩散方程、抽象空间半线性方程动力学、生物动力系统等方面建立了一系列重要的理论，在多种传染病（特别是在我国流行的一些重大传染病）的建模与防治方面作了一系列重要工作，在包括《PNAS(美国国家科学院院刊)》、《Memoirs of Amer. Math. Soc.》、《Clinical Infectious Diseases(临床传染病)》、《Arch. Ration. Mech. Anal.》和《Journal de Mathématiques Pures et Appliquées》的国际顶尖学术期刊上发表了一系列高水平的学术论文，被SCI 收录100多篇文章，受到了国内外同行的关注与大量引用，2014 年和2015年连续被汤森路透(Thomson Reuters) 列为全球高引用科学家(Highly Cited Researcher)（世界第八）；据美国数学会的MathSciNet统计，截止2016年4月底其论文被1700多位作者引用了2500多次。